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SELANK - PUBLISHED RESEARCH ON ANTI-ANXIETY PROPERTIES
Selank is a seven amino acid peptide and is derived from the Tuftsin, which is a peptide derived from immunoglobulin G. (1) Researchers have investigated Tuftsin for potentials modulation of immune cells.(2)
Since then, various analogs of Tuftsin have been discovered.(3,4) Selank also has a Pro-Gly-Pro (PGP) domain. (5) This PGP domain may enhance Selank's bioavailability in the central nervous system.(6)
BDNF and Serotonin Signaling
Research suggests that Selank may influence the levels of brain-derived neurotrophic factor (BDNF), which is an essential protein that supports neuronal survival and growth.(3) Research indicates that Selank increases the expression of BDNF in the in a brain region called the hippocampus, which is involved in memory and emotional responses.
Selank may also potentially influence serotonin signaling pathways. Serotonin modulates mood and anxiety. Research utilizing murine models indicated that Selank might be able to increase serotonin receptor levels.(7)
GABA Signaling
Studies suggest that Selank may act on the gamma-aminobutyric acid (GABA) signaling pathway. GABA is a neurotransmitter that plays a role in the brain's ability to relax and lower anxiety levels. In one study, 84 neurotransmission genes were studied. The results indicate that Selank may exert possible action via modulating the GABAergic system.(7)
Memory and Enkephalin Signaling
One clinical trial with 62 participants examined the effects of Selank on patients with anxiety. Patients were treated with either Selank or a control drug.(9) They found that Selank raised levels of tau leu-enkephalin. Enkephalins have the highest activity with the delta-opioid receptor and the mu-opioid receptor and exhibit low affinity for the kappa-opioid receptor.
This observation potentially provides on the anti-anxiety properties of Selank. In a preclinical study, researchers found that Selank improved measures of memory upon each therapeutic treatment in a preclinical model. (11)
Molecular Formula
C33H57N11O9
Molecular Weight
751.9 g/mol
Peptide ID
PubChem CID: 11765600
Alternatives Names
129954-34-3, Selanc, TP-7
The Selank peptide sold by Peptide Systems is not FDA-approved and is ONLY available for research and laboratory purposes only. You must read, agree to and adhere to our Terms and Conditions before making an order.
Selank
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CERTIFIED by 3rd party, USA registered labs with ISO 17025:2017 certification
- Certified sterile.
- Certified free of microbial contaminants (endotoxin, LPS, LAL).
- Certified free of chemical contaminants (TFA, IEX).
- Certified peptide identity (HPLC, LC-MS).
- Certified >99% pure (HPLC).